Gamma Interferon Induced Organ Regeneration

Abstract

The salamander is the only vertebrate that has a substantial capacity to regenerate severed limbs and damaged organs. A necessary condition for this response is the lack of scar formation (fibrosis) at the site of injury. I postulate that suprapharmacologic doses of gamma interferon administered locally to the site of traumatic injury or disease induced organ capacity loss might unlock regenerative capabilities in humans. Preliminary data involving a case of advanced pulmonary fibrosis (scarring) is presented wherein suprapharmacologic doses of inhaled gamma interferon induced the regeneration of functional lung parenchyma. Moreover, I postulate that potent inhibition of fibrosis in the adult human may allow the activation of embryonic development programs at the site of organ or tissue injury.