Gamma Interferon Induced Organ Regeneration

Hypothesis

Local delivery of suprapharmacologic doses of gamma interferon to the site of injury to a human organ or tissue prevents scarring (fibrosis) allowing tissue or organ regeneration in the adult. Additionally, long-term delivery of suprapharmacologic doses of gamma interferon may unlock embryonic tissue regeneration programs even after substantial scar formation (fibrosis) has occurred.

Evalution of the Hypothesis

Fibrosis inhibition is a necessary condition for limb and organ regeneration in the adult [1-4]. Suprapharmacologic doses of gamma interferon were effective in an end-stage patient with pulmonary fibrosis (severe scarring of the lung parenchyma) (see preliminary data).

Traumatic injury or injury due to disease or therapeutic interventions can result in loss of organ capacity, loss of function of limbs and unsightly scars. By administering high dose gamma interferon (on the order of 20 million units per day or more) to the site of trauma or disease, fibrosis may be suppressed to a degree that allows regeneration of the organ or tissue. Delivery of gamma interferon can be intermittent or continuous via inhalation, injection, implantable polymers or pumps.

This approach is readily testable in animal models and humans.